Factor XII, also known as Hageman Factor, is a crucial component of the intrinsic pathway in the coagulation cascade. It initiates the series of reactions leading to blood clot formation, playing a vital role in hemostasis.

Mutations or deficiencies in Factor XII can lead to serious thromboembolic complications such as venous and arterial thrombosis, ischemic stroke, and coronary heart disease. Identifying genetic variations in the F12 gene is essential for assessing patient risk profiles for these life-threatening conditions.

The FXII 46C>T RealFast™ Assay is a cutting-edge real-time PCR test designed to detect the 46C>T mutation in the F12 gene. This mutation is significant because individuals homozygous for the T allele (TT genotype) may have an increased susceptibility to thrombotic disorders.

This qualitative assay efficiently differentiates between the three possible FXII 46C>T genotypes from human DNA extracts:

• CC (Wild Type)
• CT (Heterozygous)
• TT (Homozygous Mutant)

Key Advantages of the FXII 46C>T RealFast™ Assay

• Rapid Results: Experience swift and accurate outcomes with RealFast™ technology.
• High Precision: Precisely discriminates between all three FXII 46C>T genotypes.
• Clinical Significance: Essential for identifying individuals at increased risk for venous thrombosis and related complications.
• Reliable References: Utilizes reference sequences HGVS: NG_007568.1.5046T>C and NCBI dbSNP: rs1801020 for utmost accuracy.