CYP2C9

CYP2C9 is a gene that plays a significant role in drug metabolism, encoding an enzyme in the cytochrome P450 family. This enzyme primarily metabolizes about 15% of clinically used drugs, including important medication classes such as nonsteroidal anti-inflammatory drugs (NSAIDs), antidiabetic drugs, and anticoagulants like warfarin.

The activity of the CYP2C9 enzyme varies greatly among individuals due to genetic polymorphisms in the CYP2C9 gene. These variations can significantly influence the body’s ability to process certain medications, impacting both their efficacy and safety.