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The SLCO1B1 c.521T>C RealFast™ Assay is a PCR test that detects a genetic variant responsible for simvastatin-induced myopathy, a severe side effect of statin treatment. Simvastatin is a widely prescribed statin for reducing LDL cholesterol levels, but its adverse events, including myopathy and rhabdomyolysis, are concerning.
The c.521T>C variant of the SLCO1B1 gene affects the hepatic uptake and metabolism of statins, leading to increased risk of simvastatin-induced myopathy in patients carrying the c.521C allele. The assay identifies the c.521T>C genotype in a human DNA extract, enabling personalized dose adjustment of simvastatin according to CPIC guidelines. Personalized dosing guided by genetic testing improves patient safety and reduces the risk of statin-induced myopathy associated with empirical dosing.
Introducing the SLCO1B1 c.521T>C RealFast™ Assay – the fast and accurate PCR test for detecting a genetic variant responsible for simvastatin-induced myopathy, a severe side effect of statin treatment.
Simvastatin is a widely prescribed statin for reducing LDL cholesterol levels, but its dose-dependent adverse events, including myopathy and rhabdomyolysis, are concerning. The c.521T>C variant of the SLCO1B1 gene affects the hepatic uptake and metabolism of statins, leading to increased risk of simvastatin-induced myopathy in patients carrying the c.521C allele.
The SLCO1B1 c.521T>C RealFast™ Assay identifies the c.521T>C genotype in a human DNA extract, enabling personalized dose adjustment of simvastatin according to CPIC guidelines. By avoiding the risk of simvastatin-induced myopathy, patients can benefit from the lipid-lowering effects of statin therapy without experiencing severe side effects.
Trust in Viennalab’s expertise and experience in molecular diagnostics to provide you with reliable and easy-to-use results for your laboratory workflow. Improve patient safety and reduce the risk of statin-induced myopathy associated with empirical dosing – add the SLCO1B1 c.521T>C RealFast™ Assay to your laboratory today.
The kit also includes instructions for use, as well as a protocol for the detection of SNPs in the SLCO1B1 gene using real-time PCR.
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