Subscribe to our newsletter.
Copyright 2024 © All rights Reserved Goffin Molecular Technologies
The HLA system is a complex gene cluster encoding proteins vital for immune system functionality. Pharmacogenetics studies how genetic variations impact drug response, thereby aiding in the personalized treatment for various medical conditions. Within this context, HLA-A31:01 and HLA-B15:02 have been identified as risk factors for adverse drug reactions, notably cutaneous adverse reactions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
HLA-A3101 has been specifically implicated in adverse reactions to the antiepileptic drug carbamazepine. Patients with this allele have an increased risk of developing hypersensitivity reactions that can range from mild skin rashes to severe conditions such as TEN. The underlying mechanism is thought to involve the formation of a drug-peptide complex that activates cytotoxic T-cells, triggering an immune response.
Subscribe to our newsletter.