PIK3CA-11 mutations cfDNA

PIK3CA mutations occur in approximately 40% of patients with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancer were it is localized mainly on Exons 9 and 20. PIK3CA mutations are highly frequent in other tumor entities like Endometrium, Colon, Urinary tract, Cervix and the large intestine (1-5).