CVD StripAssay

The CVD StripAssay is a diagnostic tool specifically designed for the precise identification of genetic mutations associated with cardiovascular diseases (CVD). It utilizes polymerase chain reaction (PCR) and reverse-hybridizationtechniques to deliver highly accurate results for in vitro diagnostics. This assay covers 12 key mutations, providing healthcare professionals and researchers with deep insights into an individual’s genetic predisposition to CVD.

Key Mutations Covered by the CVD StripAssay

1. FV G1691A (Leiden): Mutation linked to an increased risk of thrombosis.
2. FV H1299R (R2): Variant that further modifies Factor V function, impacting clotting risk.
3. Prothrombin G20210A: Mutation associated with an elevated risk of blood clots and venous thromboembolism.
4. Factor XIII V34L: Variation that affects fibrin stability, influencing clot formation and cardiovascular health.
5. Beta-Fibrinogen -455G>A: Affects fibrinogen levels, altering clotting mechanisms and cardiovascular risk.
6. PAI-1 4G/5G: Involved in fibrinolysis, with genetic variations influencing clot breakdown and thrombotic risk.
7. GPIIIa L33P (HPA-1): Affects platelet glycoproteins, increasing the risk of thrombotic events.
8. MTHFR C677T and A1298C: Mutations related to homocysteine levels, which can contribute to cardiovascular disease.
9. ACE I/D: Insertion or deletion in the ACE gene impacts blood pressure regulation and cardiovascular health.
10. Apo B R3500Q: Linked to familial hypercholesterolemia and elevated cholesterol levels, increasing CVD risk.
11. Apo E2/E3/E4: Variations that influence lipid metabolism and are linked to different risks of developing cardiovascular diseases.

Applications and Benefits

• Personalized Medicine: By identifying key mutations, the CVD StripAssay allows for tailored prevention and treatment strategies, helping healthcare professionals address an individual’s specific cardiovascular risk factors.
• Early Detection: Early identification of genetic predispositions enables proactive management, potentially reducing the incidence of cardiovascular diseases.

In conclusion, the CVD StripAssay is a powerful diagnostic tool that provides a comprehensive genetic analysis related to cardiovascular diseases. By covering 12 critical mutations, it supports personalized healthcare, offering deeper insights into patient risk factors while contributing to ongoing cardiovascular research.

• Lysis Solution (50 ml)
• GENXTRACTTM Resin (5 ml)
• Amplification Mix A (yellow cap, 500 µl)
• Amplification Mix B (green cap, 500 µl)
• Taq Dilution Buffer (transparent cap, 500 µl)
• DNAT (blue cap, 1.5 ml)
• Typing Trays (3)
• Teststrips (20)
• Hybridization Buffer (white cap, 25 ml)
• Wash Solution A (white cap, 80 ml)
• Conjugate Solution (25 ml)
• Wash Solution B (80 ml)
• Color Developer (25 ml)
• Instructions for use (1)
• CollectorTM Sheet (1)