SLCO1B1 PCR Assay
The SLCO1B1 c.521T>C RealFast™ Assay is a PCR test that detects a genetic variant responsible for simvastatin-induced myopathy, a severe side effect of statin treatment. Simvastatin is a widely prescribed statin for reducing LDL cholesterol levels, but its adverse events, including myopathy and rhabdomyolysis, are concerning. The c.521T>C variant of the SLCO1B1 gene affects the hepatic uptake and metabolism of statins, leading to increased risk of simvastatin-induced myopathy in patients carrying the c.521C allele. The assay identifies the c.521T>C genotype in a human DNA extract, enabling personalized dose adjustment of simvastatin according to CPIC guidelines. Personalized dosing guided by genetic testing improves patient safety and reduces the risk of statin-induced myopathy associated with empirical dosing.
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This kit in detail
The SLCO1B1 c.521T>C RealFast™ Assay is a PCR test that detects a genetic variant responsible for simvastatin-induced myopathy, a severe side effect of statin treatment. Simvastatin is a widely prescribed statin for reducing LDL cholesterol levels, but its adverse events, including myopathy and rhabdomyolysis, are concerning.
The c.521T>C variant of the SLCO1B1 gene affects the hepatic uptake and metabolism of statins, leading to increased risk of simvastatin-induced myopathy in patients carrying the c.521C allele. The assay identifies the c.521T>C genotype in a human DNA extract, enabling personalized dose adjustment of simvastatin according to CPIC guidelines. Personalized dosing guided by genetic testing improves patient safety and reduces the risk of statin-induced myopathy associated with empirical dosing.
- Personalized medicine
- Reducing the risk of potentially dangerous side effects
- Fast and accurate detection of the SLCO1B1 c.521T>C variant
- Can be performed in a standard laboratory setting
- Cost-effective solution for determining SLCO1B1 genotype
Introducing the SLCO1B1 c.521T>C RealFast™ Assay – the fast and accurate PCR test for detecting a genetic variant responsible for simvastatin-induced myopathy, a severe side effect of statin treatment.
Simvastatin is a widely prescribed statin for reducing LDL cholesterol levels, but its dose-dependent adverse events, including myopathy and rhabdomyolysis, are concerning. The c.521T>C variant of the SLCO1B1 gene affects the hepatic uptake and metabolism of statins, leading to increased risk of simvastatin-induced myopathy in patients carrying the c.521C allele.
The SLCO1B1 c.521T>C RealFast™ Assay identifies the c.521T>C genotype in a human DNA extract, enabling personalized dose adjustment of simvastatin according to CPIC guidelines. By avoiding the risk of simvastatin-induced myopathy, patients can benefit from the lipid-lowering effects of statin therapy without experiencing severe side effects.
Trust in Viennalab’s expertise and experience in molecular diagnostics to provide you with reliable and easy-to-use results for your laboratory workflow. Improve patient safety and reduce the risk of statin-induced myopathy associated with empirical dosing – add the SLCO1B1 c.521T>C RealFast™ Assay to your laboratory today.
- DNA Extraction Kit: A kit containing all the reagents necessary for the extraction of genomic DNA from a blood or saliva sample, including DNA extraction buffer, proteinase K, and magnetic beads.
- PCR Mix: A ready-to-use mix containing all the reagents necessary for the PCR amplification of the SLCO1B1 gene region of interest.
- SLCO1B1 Primer Mix: A mix of primers specific for the SLCO1B1 gene region of interest.
- Probe Mix: A mix of probes specific for the detection of SNPs in the SLCO1B1 gene.
- Control DNA: A synthetic DNA that is added to the sample as an internal control to ensure that the assay is working correctly.
- DNase/RNase-free Water: Water that has been treated to remove contaminating DNases and RNases, which can degrade the extracted DNA.
The kit also includes instructions for use, as well as a protocol for the detection of SNPs in the SLCO1B1 gene using real-time PCR.
Datasheets and regulatory documentation
Everything your quality team needs for evaluation and procurement.
Instructions for Use
Brochure
Frequently paired with this kit
Other assays and instruments lab teams add alongside the SLCO1B1 PCR Assay.
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