β-Thal Modifier StripAssay
The β-Thal Modifier StripAssay® from Viennalab is a molecular diagnostic test designed to identify genetic variants associated with beta-thalassemia, a group of inherited blood disorders that affect the production of hemoglobin. This qualitative test can detect up to 11 different mutations associated with beta-thalassemia and has high sensitivity and specificity, making it a reliable tool for identifying patients with the condition. It is easy to use and can be performed on a variety of sample types. The assay can be used for both research and clinical applications, providing a valuable tool for genetic counseling, carrier screening, and prenatal diagnosis.
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This kit in detail
The β-Thal Modifier StripAssay® from Viennalab is a molecular diagnostic test designed to identify genetic variants associated with beta-thalassemia, a group of inherited blood disorders that affect the production of hemoglobin. This qualitative test can detect up to 11 different mutations associated with beta-thalassemia and has high sensitivity and specificity, making it a reliable tool for identifying patients with the condition.
It is easy to use and can be performed on a variety of sample types. The assay can be used for both research and clinical applications, providing a valuable tool for genetic counseling, carrier screening, and prenatal diagnosis.
- Detects up to 11 genetic variants
- Highly sensitive and specific (98% and 100%, respectively)
- Easy-to-use with no specialized equipment required
- Works with multiple sample types
- Useful for research and clinical applications
The β-Thal Modifier StripAssay® from Viennalab is a molecular diagnostic test designed to identify genetic variants associated with beta-thalassemia, a group of inherited blood disorders that affect the production of hemoglobin. This assay is a reliable tool for identifying patients who may carry these mutations, allowing for earlier diagnosis and appropriate treatment.
The β-Thal Modifier StripAssay® utilizes a reverse hybridization method, in which PCR amplification is followed by hybridization of the biotin-labeled PCR product to specific probes immobilized on a nitrocellulose membrane strip. This allows for the detection of various beta-globin gene mutations through the appearance of specific hybridization signals on the strip.
The β-Thal Modifier StripAssay® is a qualitative test that can detect various beta-thalassemia mutations, including common mutations associated with beta-thalassemia and other rare mutations. The test is designed to detect up to 11 different mutations in a single reaction, providing a comprehensive diagnostic tool for patients with beta-thalassemia.
One of the key advantages of the β-Thal Modifier StripAssay® is its high sensitivity and specificity. The assay has been shown to have a sensitivity of 98% and a specificity of 100%, making it a highly reliable tool for identifying patients with beta-thalassemia. Additionally, the assay is easy to use and does not require specialized equipment, making it accessible for laboratories with limited resources.
The β-Thal Modifier StripAssay® can be used for both research and clinical applications, providing a valuable tool for genetic counseling, carrier screening, and prenatal diagnosis. The test can be performed on a variety of sample types, including whole blood, dried blood spots, and buccal swabs, making it a flexible and versatile tool for genetic testing.
In summary, the β-Thal Modifier StripAssay® from Viennalab is a fast, reliable, and easy-to-use molecular diagnostic tool for identifying genetic variants associated with beta-thalassemia. The assay’s high sensitivity and specificity, along with its ability to detect multiple mutations in a single reaction, make it a valuable tool for both research and clinical applications.
- PCR mix
- Strip with immobilized probes
- Positive control DNA
- Negative control DNA
- Sterile water
These components are used to perform a reverse hybridization assay, in which PCR amplification is followed by hybridization of the biotin-labeled PCR product to specific probes immobilized on a nitrocellulose membrane strip. The appearance of specific hybridization signals on the strip is used to detect various beta-globin gene mutations.
Datasheets and regulatory documentation
Everything your quality team needs for evaluation and procurement.
Instructions for Use
Frequently paired with this kit
Other assays and instruments lab teams add alongside the β-Thal Modifier StripAssay.
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