Imegen-Alpha-1-AT
The imegen® Alpha-1-AT kit is an advanced molecular biology tool for the detection of specific genetic mutations associated with alpha-1 antitrypsin deficiency, including the Glu342Lys (PI-Z) and Glu264Val (PI-S) variants in the SERPINA gene. The kit includes master mixes, oligonucleotides, and fluorescent probes for real-time PCR analysis, as well as a synthetic positive control for qualitative assessment. It is compatible with a wide range of real-time PCR platforms, supporting accurate and reliable genetic analysis. Note that this kit is for Research Use Only (RUO).
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This kit in detail
The imegen® Alpha-1-AT kit is an advanced molecular biology tool for the detection of specific genetic mutations associated with alpha-1 antitrypsin deficiency, including the Glu342Lys (PI-Z) and Glu264Val (PI-S) variants in the SERPINA gene. The kit includes master mixes, oligonucleotides, and fluorescent probes for real-time PCR analysis, as well as a synthetic positive control for qualitative assessment. It is compatible with a wide range of real-time PCR platforms, supporting accurate and reliable genetic analysis.
Note that this kit is for Research Use Only (RUO).
- Genetic Mutation Detection
- Real-time PCR
- High Sensitivity
- Synthetic Controls
The imegen® Alpha-1-AT Kit: Advanced Genetic Analysis
Understanding genetic variation is essential in modern molecular biology. The imegen® Alpha-1-AT Kit (IMG-211) is a precise and reliable tool developed for the detection of specific mutations associated with alpha-1 antitrypsin deficiency. It targets the Glu342Lys (PI-Z; rs28929474; c.1096G>A) and Glu264Val (PI-S; rs17580; c.863A>T) variants within the SERPINA1 gene.
Key Features:
- Mutation Detection: Designed for accurate identification of PI-Z and PI-S variants within the SERPINA1 gene.
- Real-time PCR Technology: Utilizes real-time PCR for sensitive and specific DNA amplification and detection.
- High Sensitivity: Capable of detecting low levels of target DNA with consistent performance.
- Synthetic Controls: Includes synthetic positive controls representing heterozygous genotypes to support assay performance and verification.
Validation and Ease of Use:
The imegen® Alpha-1-AT Kit has been validated using characterized samples and synthetic DNA, demonstrating robust performance in mutation detection. The workflow requires 100 ng of genomic DNA from peripheral blood and is designed for straightforward integration into standard laboratory procedures. Clear instructions support efficient implementation.
Conclusion:
The imegen® Alpha-1-AT Kit provides a reliable solution for the analysis of genetic variants associated with alpha-1 antitrypsin deficiency. With its strong technical performance and compatibility with a wide range of real-time PCR platforms, it supports consistent and high-quality molecular biology workflows.
PI-S Master Mix, PI-Z Master Mix, General Master Mix and Positive Control
Datasheets and regulatory documentation
Everything your quality team needs for evaluation and procurement.
Instructions for Use
Imegen-Alfa-1-AT
Frequently paired with this kit
Other assays and instruments lab teams add alongside the Imegen-Alpha-1-AT.
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Tell us the platforms and throughput you’re planning for and our specialists will put together a clear proposal with the right documentation, no public pricing, just a considered answer.
