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VeriDose Core Panel for Targeted PGx Testing
VeriDose offers a streamlined approach to pharmacogenetic testing with its Core Panel, designed for clinical laboratories seeking high-impact, guideline-driven content. The VeriDose® Core Panel focuses on 85 SNPs and INDELs across 16 genes, all highly relevant in drug metabolism and supported by international PGx recommendations (Tier 1 and Tier 2). This targeted panel simplifies implementation without compromising depth, allowing labs to report clinically actionable genotypes linked to response, efficacy, and adverse drug reactions. It is ideal for integration into precision medicine workflows and can be used in parallel with the VeriDose CYP2D6 CNV Panel for extended copy number analysis. Compatible with Agena Bioscience’s MassARRAY® system, the VeriDose Core Panel supports clear reporting of diplotypes, haplotypes, and CNVs. With ready-to-use, pre-validated content and flexible customization options, this panel enables molecular labs to scale quickly with trusted content.
Quote-based, no public pricing. Add to your quote and our specialists put together a proposal with the right documentation, typically within 24 hours.
This kit in detail
VeriDose offers a streamlined approach to pharmacogenetic testing with its Core Panel, designed for clinical laboratories seeking high-impact, guideline-driven content. The VeriDose® Core Panel focuses on 85 SNPs and INDELs across 16 genes, all highly relevant in drug metabolism and supported by international PGx recommendations (Tier 1 and Tier 2).
This targeted panel simplifies implementation without compromising depth, allowing labs to report clinically actionable genotypes linked to response, efficacy, and adverse drug reactions. It is ideal for integration into precision medicine workflows and can be used in parallel with the VeriDose CYP2D6 CNV Panel for extended copy number analysis.
Compatible with Agena Bioscience’s MassARRAY® system, the VeriDose Core Panel supports clear reporting of diplotypes, haplotypes, and CNVs. With ready-to-use, pre-validated content and flexible customization options, this panel enables molecular labs to scale quickly with trusted content.
- Covers 85 variants across 16 drug-metabolism genes
- VeriDose-targeted content aligned with Tier 1/2 PGx guidelines
- Run with CYP2D6 CNV Panel for expanded pharmacogenetic analysis
- Clear, reportable results including diplotypes and haplotypes
What is in the VeriDose Core Panel
The VeriDose Core Panel is a foundational PGx solution designed for high-throughput clinical pharmacogenetic testing. It includes:
- 85 SNPs and INDELs across 16 clinically significant genes (e.g., CYP2C19, CYP2D6, SLCO1B1, TPMT)
- Coverage based on Tier 1 and Tier 2 recommendations from key pharmacogenetics consortia (e.g., CPIC, DPWG)
- Full compatibility with the VeriDose CYP2D6 CNV Panel for extended copy number detection
- Pre-configured assays for use with the Agena MassARRAY® system
By consolidating essential variants in a single panel, VeriDose enables laboratories to provide high-quality, actionable PGx data without excessive assay complexity.
Role of the VeriDose Targets in Disease and Treatment
The genes targeted in the VeriDose-targeted panel are integral to drug metabolism, transport, and response. Understanding patient-specific variants in these genes can improve therapeutic outcomes, reduce adverse effects, and inform dosing strategies. Examples include:
- CYP2D6 and CYP2C19: Impact response to antidepressants, opioids, and proton pump inhibitors
- TPMT and NUDT15: Linked to thiopurine toxicity in cancer and IBD treatments
- SLCO1B1: Associated with statin-induced myopathy risk
- VKORC1 and CYP2C9: Crucial for warfarin sensitivity and dosing
By identifying VeriDose-positive genotypes in these genes, labs can support the clinical decision-making process with evidence-based pharmacogenetic insights.
About the VeriDose® Core Panel
The VeriDose Core Panel by Agena Bioscience provides a harmonized PGx testing platform for laboratories ready to move beyond single-gene analysis. This panel enables:
- Standardized and reproducible reporting of Tier 1/2 variants
- Rapid implementation through pre-designed and validated assay content
- Scalability-run standalone or in combination with CYP2D6 CNV analysis
- Reliable software interpretation for diplotype and haplotype generation
Backed by extensive validation and trusted by PGx leaders, VeriDose helps labs deliver consistent and confident results, driving personalized medicine initiatives forward.
Principle and Workflow
The VeriDose Core Panel operates on Agena’s MassARRAY® system, leveraging matrix-assisted laser desorption/ionization–time of flight (MALDI-TOF) technology for genotyping. The workflow includes:
- DNA Extraction from clinical sample
- Multiplex PCR Amplification of target SNPs and INDELs
- Primer Extension and Detection via MALDI-TOF
- Automated Data Interpretation using Agena’s software
The streamlined protocol reduces hands-on time while maintaining high throughput, making the VeriDose panel ideal for both centralized laboratories and pharmacogenetic service providers.
Clinical Application
The VeriDose Core Panel supports a wide range of clinical applications, including:
- Medication guidance in psychiatry, cardiology, oncology, and pain management
- Risk reduction for adverse drug reactions and treatment failure
- Pre-emptive PGx screening for high-risk populations or polypharmacy patients
- Integration into electronic health records (EHRs) for clinical decision support
By enabling personalized prescribing, VeriDose helps clinicians tailor therapies based on the genetic makeup of each patient-enhancing safety and efficacy.
Datasheets and regulatory documentation
Everything your quality team needs for evaluation and procurement.
Frequently paired with this kit
Other assays and instruments lab teams add alongside the VeriDose Core Panel for Targeted PGx Testing.
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