FMF

Familial Mediterranean Fever (FMF) is a hereditary disorder primarily affecting populations around the Mediterranean Sea, though it can occur in other ethnic groups as well. Characterized by recurrent episodes of fever and inflammation, FMF typically manifests in painful “attacks” affecting the abdomen, chest, or joints. The condition is caused by mutations in the MEFV gene, leading to irregularities in the protein pyrin, which plays a role in inflammation control. While there’s no cure, treatment usually involves medication like colchicine to manage symptoms and prevent complications such as amyloidosis. Early diagnosis and consistent treatment can help manage the symptoms effectively.