Genetic Predispositions · Catalog
Factor V Leiden
About Factor V Leiden
The Genetic Basis of Factor V Leiden
Factor V Leiden is caused by a mutation in the Factor V gene, leading to a change in the protein’s structure. The mutation results in an alteration of the Factor V protein, making it resistant to being inactivated by a natural anticoagulant called activated protein C (APC). As a result, the mutated Factor V remains active in the clotting process for a longer time, increasing the risk of blood clot formation.
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