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The BRCA NGS Panel truNGS® BRCA Plus Kit is a comprehensive next-generation sequencing solution for accurate detection of germline and somatic variants. Specifically designed for BRCA1, BRCA2, and STK11 genes, this panel identifies single nucleotide variants (SNVs) and insertions/deletions (Indels) from nucleic acid extracted from blood, fresh frozen tissue, or formalin-fixed paraffin-embedded (FFPE) samples.
The workflow integrates advanced library preparation with hybrid capture and target enrichment, ensuring robust sequencing performance. Compatible with both Illumina and MGI platforms, this BRCA NGS Panel delivers high sensitivity, reproducibility, and clinically relevant insights.
With its integrated bioinformatics workflow and automated reporting, the truNGS® BRCA Plus Kit streamlines variant detection and interpretation. It empowers laboratories in oncology, molecular diagnostics, and clinical genetics to provide reliable results that support risk assessment, treatment selection, and improved patient management in hereditary and sporadic cancers.
The truNGS® BRCA Plus Kit includes all essential reagents for a targeted BRCA NGS Panel. It enables the detection of clinically relevant variants in BRCA1, BRCA2, and STK11 genes. Designed for both germline and somatic variant analysis, the panel identifies single nucleotide variants (SNVs) and insertions/deletions (Indels) with high precision. The kit supports DNA extracted from blood, fresh frozen tissue, and formalin-fixed paraffin-embedded (FFPE) samples. With integrated bioinformatics tools, it delivers reproducible and easy-to-interpret results.
BRCA1 and BRCA2 mutations are central to hereditary breast and ovarian cancers. These genes are crucial for DNA repair, and pathogenic variants dramatically increase the lifetime risk of cancer. STK11, another target in the BRCA NGS Panel, is linked to Peutz-Jeghers syndrome and elevated cancer predisposition. Identifying both germline and tumor-specific mutations in these genes is vital for early diagnosis, therapy decisions, and family counseling. By offering accurate detection, the panel supports clinicians in guiding treatment and preventive care strategies.
The truNGS® BRCA Plus Kit provides laboratories with a validated, CE-marked NGS solution for BRCA testing. It has been optimized for use on Illumina and MGI platforms, ensuring flexibility and performance across different sequencing workflows. Integrated bioinformatics pipelines simplify analysis, minimizing complexity while maximizing accuracy. Developed for oncology and molecular diagnostics professionals, this BRCA NGS Panel combines precision with usability, helping labs meet clinical demands for actionable genetic insights.
The workflow of the truNGS® BRCA Plus Kit consists of two core steps:
Library Preparation – DNA fragmentation, adapter ligation, and PCR amplification create high-quality sequencing libraries.
Hybrid Capture and Target Enrichment – Libraries are pooled, hybridized with specific probes targeting BRCA1, BRCA2, and STK11, then enriched and amplified.
Sequencing-ready libraries are compatible with Illumina and MGI platforms. The integrated bioinformatics system processes the raw data, identifies SNVs and Indels, and generates clinical-grade reports. This streamlined process ensures consistent and reproducible detection of BRCA variants.
The BRCA NGS Panel is designed for both clinical and research use, offering:
Hereditary cancer testing – Detect germline mutations associated with inherited breast and ovarian cancer.
Somatic tumor profiling – Identify actionable tumor-specific variants for therapy guidance.
Risk assessment – Screen carriers of BRCA1, BRCA2, or STK11 variants to support preventive strategies.
Research applications – Advance understanding of genetic contributions to cancer development.
By combining technical excellence with bioinformatics support, the truNGS® BRCA Plus Kit enables laboratories to provide high-value results that improve patient outcomes and inform evidence-based oncology.
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